Footnotes

Abbreviations: CALGB = Cancer and Leukemia Group B; COX-2 = cyclooxygenase-2; DHFR = dihydrofolate reductase; EORTC = European Organization for Research and Treatment of Cancer; EPP = extrapleural pneumonectomy; GARFT = glycinamide ribonucleotide formyltransferase; IMIG = International Mesothelioma Interest Group; MPM = malignant pleural mesothelioma; P/D = pleurectomy/decortication; SV = simian virus; TS =thymidylate synthetase; VEGF = vascular endothelial growth factor Dr. Pistolesi is a consultant of Eli Lilly and Company in the phase III study of pemetrexed in malignant pleural mesothelioma. Dr. Rusthoven is a consultant and former employee of Eli Lilly and Company.